![]() It also measured the supplementary effects with 400 ml of non-enriched milk daily for 14 days on vitamin B-12 status by measuring the changes in plasma holo-TC, vitamin B-12 and total homocysteine (Hcy) concentrations. The present study measured the effects of supplementation with 600 ml of skimmed buffalo milk not enriched with vitamin B-12, during the day on circulating holo-TC concentration. ![]() The option of increasing overall vitamin B-12 status of deficient population is either fortification or targeted dietary recommendation. Therefore, it is important to establish whether dietary intervention by the available natural source can improve vitamin B-12 status in Indian vegetarian population and protect from diverse disorders. Several morbidities may be associated with low-normal vitamin B-12 status (< 148 pmol/L). Recently, low plasma vitamin B-12 concentrations in pregnancy have been shown to be associated with diminished neuro-cognitive performance in offspring. The deficiency of vitamin B-12 has been associated with diverse disorders throughout the life span, from birth defects such as shunted growth, neural tube defects, anemia to hyperhomocysteinemia and neuro-cognitive disorders in adulthood. The increase in plasma holo-TC concentration after vitamin B-12 load provided experimental evidence that the increase was due to recent vitamin B-12 absorption. Two main etiologic factors play a role in developing vitamin B-12 deficiency inadequate dietary intake and/or vitamin B-12 mal-absorption.īhat et al have used the rise in plasma holotranscobalamin II ( holo-TC) concentrations with a smaller dose of cyanocobalamin (6 μ g) in vitamin B-12 deficient Indians as a marker of absorption. Dhopeshwarkar et al showed that asymptomatic Indian lacto vegetarians, who make up more than half of the Indian population, have distinctly low vitamin B-12 concentrations than non-vegetarians which was confirmed by studies from different geographic regions of India. Wokes et al systematically compared a group of US, Dutch and British vegans with non-vegetarians from those same countries and found that many of the vegans had significantly lower vitamin B-12 concentrations than did non-vegetarians. The Framingham Offspring Study first observed that vitamin B-12 from milk was better absorbed than meat. They further stated that daily dietary intake of 6-10 μg of vitamin B-12 ensured the maximum plasma vitamin B-12 concentration in persons with adequate vitamin B-12 absorption suggesting that the current RDA of 2.4 μ g/day is also insufficient. In a large population-based study, Vogiatzoglou et al found a significant association between total daily dietary intake of vitamin B-12 and plasma vitamin B-12 concentrations. Howard et al concluded that high frequency of mildly abnormal cobalamin status in the elderly was not due to poor intake of cobalamin, whereas, Framingham Offspring and Danish Study showed significant associations between dietary intake of vitamin B-12 and plasma concentrations. The relation between dietary intake and vitamin B-12 status has been studied in different populations with conflicting results. milk, yogurt, and cheese/butter, tea/coffee with milk or from vitamin B-12 supplements. ![]() Vitamin B-12 intake by Indians derives from natural food products, i.e. The recommended dietary allowance (RDA) of vitamin B-12 for adults in India is 1.0 μ g/day, whereas in USA it is 2.4 μ g/day. Plasma holotranscoabalamin II (day-1, 15, 16, 30), vitamin B-12, folate, total homocysteine, creatinine and hematoloical parameters (day-1, 15, 30), and milk vitamin B-12 concentrations (day-15, 16, 30) were measured.ĭietary reference intake of vitamin B-12 was defined as the amount required to prevent the overt vitamin B-12 deficiency that causes megaloblastic anemia and to maintain plasma concentrations above 148 pmol/L. Subjects from deficient group continued to drink 400 ml of milk daily for next 14 days and blood was collected on day-30. Next day blood was collected for plasma holotranscobalamin II measurement. of non-enriched buffalo milk (200 × 3) during the day along with their usual diet. They continued their regular diet for next fourteen days and on day-15, blood of all 51 participants was collected, plasma vitamin B-12 concentration was measured and were divided into two groups Normal (vitamin B-12 >148 pmol/L, n = 22) and Vitamin B-12 deficient (<148 pmol/L, n = 29), the remaining plasma was stored. Blood from ten participants (4 males and 6 females) was collected (day-1). Fifteen male and 36 female, young healthy post-graduate volunteers participated.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |